Metallation reactions of isocyanides.

Solvent-Free Multicomponent Reactions of Dithiocarbamates, Activated Acetylenes and Isocyanides

An efficient method to synthesis the 2H-pyrans using three component reactions of dithiocarbamats, activated acetylenes and isocyanides in water as the solvent is described. In these reactions, synthesis of 2H-pyrans is possible based on the one-pot reaction and without using any catalyst. The mild reaction conditions and high yields of the products exhibit synthetic advantage of these methods.

solvent-free multicomponent reactions of dithiocarbamates, activated acetylenes and isocyanides

Chemistry of the isocyanides and their multicomponent reactions , including their libraries – the initiatives of Ivar Ugi

Highly selective introduction of heteroatom groups to isocyanides and its application to electrocyclic reactions*

Photoinduced cyclization of o-alkenylaryl isocyanides with (PhS)2 in the presence of (PhTe)2 affords the corresponding bisthiolated indene derivatives in good yields via radical cyclization process by thio radical. The procedure can be applied to the construction of tetracyclic systems by using bis(o-aminophenyl) disulfides in place of (PhS)2. In sharp contrast, when o-alkynylaryl isocyanides a...

1 Metal preferences and metallation

The metal-binding preferences of most metalloproteins do not match their metalrequirements. Thus, metallation of an estimated 30% of metalloenzymes is aided by metaldelivery systems, with ~25% acquiring preassembled metal-cofactors. The remaining ~70% are presumed to compete for metals from buffered metal-pools. Metallation is further aided by maintaining the relative concentrations of these po...